Telomere length behaves as biomarker of somatic redundancy rather than biological age
نویسندگان
چکیده
منابع مشابه
Telomere length behaves as biomarker of somatic redundancy rather than biological age.
Biomarkers of aging are essential to predict mortality and aging-related diseases. Paradoxically, age itself imposes a limitation on the use of known biomarkers of aging because their associations with mortality generally diminish with age. How this pattern arises is, however, not understood. With meta-analysis we show that human leucocyte telomere length (TL) predicts mortality, and that this ...
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T elomeres are unique protein–DNA structures that comprise the termini of eukaryotic linear chromosomes (for review see references 1, 2). Telomeric DNA does not contain protein-encoding genes but rather consists of G-rich hexanu-cleotide repeats that in vertebrate cells are (TTAGGG) n sequences. Based on studies initially carried out in yeast and other single cell organisms, it appears that tel...
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Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during mitosis. Short telomeres induce cellular senescence. As an indicator of oxidative stress and senescence (2 processes thought to be fundamental to aging), telomere length is hypothesized to be a biomarker of aging. This hypoth...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2013
ISSN: 1474-9718
DOI: 10.1111/acel.12050